Philip Allan Seymour

The paper shows that mechanical sorting, driven by adhesion and contractility differences, maintains basal-luminal compartmentalization and influences lineage outcomes in glandular epithelia.

The paper investigates how lumen morphology in pancreatic organoids is controlled by the balance between cell proliferation rate and lumen pressure, showing that lower pressure and faster proliferation lead to more complex lumen shapes.

This study identifies LINC00673, a long noncoding RNA from a Sox9-associated super-enhancer, as critical for pancreatic regeneration and PDAC initiation by regulating cell-autonomous and non-cell-autonomous processes.

This study shows Jag1 modulates oscillatory Dll1-Notch-Hes1 signaling in pancreatic progenitors to coordinate their growth and fate, with Jag1 also specifying most bipotent progenitors.

This study shows NOTCH signaling regulates early thymic epithelial progenitor cells and mTEC lineage emergence during fetal thymus development.

This study identifies direct Hes1 target genes in pancreatic progenitor cells, revealing Notch signaling's role in repressing tip cell fate through repression of key regulators like Ptf1a and Gata4.