Neuroectoderm phenotypes in a human stem cell model of O-GlcNAc transferase intellectual disability
Marta Murray, Lindsay Davidson, Andrew T. Ferenbach, Dirk J. Lefeber, Daan M. F. van Aalten
This study investigates OGT-CDG using stem cells, finding disrupted O-GlcNAc homeostasis and morphology during neuroectoderm differentiation but preserved stemness and differentiation potential.
bioRxiv · Sep 18, 2023 · PreprintDevelopmental Biology