Lindsay Davidson

The paper develops a high-throughput system to study segmentation clock phase responses in hiPSC-derived somitoids using image-based screening and mathematical modeling.

This study shows DNA replication enables chromatin changes during human iPSC differentiation by allowing protein access to nascent DNA, with H3K9 methylation and proteins like ERH and SETDB1 playing key roles.

This study identifies the CaMKII-RNMT axis as a mechanism controlling activity-dependent RNA dynamics and neuronal morphogenesis through phosphorylation and degradation of RNMT.

This study shows that a NOTCH1 mutation affects NICD stability and disrupts segmentation clock function in hiPSC-derived PSM cells and somitoids.

This study compares the proteomes of human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs), finding quantitative differences in protein expression affecting growth, metabolism, and secreted factors.

The paper develops fluorescent reporter tools in human pluripotent stem cells to study neural development through live imaging of cell behaviors.

This study investigates OGT-CDG using stem cells, finding disrupted O-GlcNAc homeostasis and morphology during neuroectoderm differentiation but preserved stemness and differentiation potential.

This study shows that human spinal cord differentiation in vitro is faster than in vivo and stalls when grafted into a different species, highlighting the role of extrinsic signals.

The paper shows SRPK regulates ubiquitin-dependent neurodevelopmental signalling by phosphorylating RNF12, linking SRPK mutations to intellectual disability.

The paper develops a protocol to generate human neuromesodermal and spinal cord progenitors in vitro, validates it with RNA-Seq, and identifies new pathways in neural differentiation.