{Phi}X174 Attenuation by Whole Genome Codon Deoptimization
James T. Van Leuven, Martina M. Ederer, Katelyn Burleigh, LuAnn Scott, Randall A. Hughes, Vlad Codrea, Andrew D. Ellington, Holly A. Wichman, Craig R. Miller
This study shows that systematically introducing synonymous mutations in bacteriophage {Phi}X174 reduces viral fitness, but the effects are non-linear and gene-dependent.
Genome Biology and Evolution · Oct 9, 2020Peer-reviewedGenomics