A patient-derived amyotrophic lateral sclerosis blood-brain barrier cell model reveals focused ultrasound-mediated anti-TDP-43 antibody delivery.
Joanna Marta Wasielewska, Mauricio Castro Cabral-da-Silva, Martina Pecoraro, Tam Hong Nguyen, Vincenzo La Bella, Lotta E. Oikari, Lezanne Ooi, Anthony Robert White
This study develops a human ALS patient-derived BBB model to show focused ultrasound with microbubbles enhances anti-TDP-43 antibody delivery across the BBB in vitro.
bioRxiv · Feb 22, 2024 · PreprintNeuroscience