Mauricio Castro Cabral-da-Silva

Alzheimer's disease induced neurons bearing PSEN1 mutations exhibit reduced excitability

This study investigates how PSEN1 mutations in Alzheimer's disease affect neuronal excitability using iPSC-derived neurons and finds reduced excitability and altered Kv/Nav channel currents in mutant neurons.

A patient-derived amyotrophic lateral sclerosis blood-brain barrier cell model reveals focused ultrasound-mediated anti-TDP-43 antibody delivery.

This study develops a human ALS patient-derived BBB model to show focused ultrasound with microbubbles enhances anti-TDP-43 antibody delivery across the BBB in vitro.

Identification of repurposable cytoprotective drugs for Vanishing White Matter Disease

This study identifies FDA-approved drugs that protect astrocytes in Vanishing White Matter Disease by targeting the integrated stress response and mitochondrial stress.