Tam Hong Nguyen

Impact of wildfire smoke and diesel exhaust on inflammatory response in aging human microglia

This study examines how wildfire smoke and diesel exhaust affect inflammatory responses in aging human microglia, showing distinct temporal and molecular effects on oxidative stress and cytokine profiles.

A patient-derived amyotrophic lateral sclerosis blood-brain barrier cell model reveals focused ultrasound-mediated anti-TDP-43 antibody delivery.

This study develops a human ALS patient-derived BBB model to show focused ultrasound with microbubbles enhances anti-TDP-43 antibody delivery across the BBB in vitro.

ALS monocyte-derived microglia reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression.

This paper develops a method to generate monocyte-derived microglia from ALS patient blood, revealing functional impairments and pathological features associated with disease progression.

3D models of Alzheimer's disease patient microglia recapitulate disease phenotype and show differential drug responses compared to 2D

This study develops 3D models of Alzheimer's patient microglia that show distinct disease features and drug responses compared to 2D cultures.