Lezanne Ooi

This study investigates how PSEN1 mutations in Alzheimer's disease affect neuronal excitability using iPSC-derived neurons and finds reduced excitability and altered Kv/Nav channel currents in mutant neurons.

The paper identifies molecular and anatomical diversity in human cortical astrocytes and links adversity and glucocorticoid signalling to glutamate-related synaptic dysfunction in psychiatric disorders.

The paper introduces IL-VIS, a machine learning pipeline that incrementally learns and visualizes progression trajectories for longitudinal data, demonstrating its utility on brain organoid electrophysiological data.

The paper investigates REST and RCOR gene expression in human neurons and astrocytes using 2D and 3D stem cell models, finding cell-type-specific expression patterns.

This study develops a human ALS patient-derived BBB model to show focused ultrasound with microbubbles enhances anti-TDP-43 antibody delivery across the BBB in vitro.

This study identifies FDA-approved drugs that protect astrocytes in Vanishing White Matter Disease by targeting the integrated stress response and mitochondrial stress.