Development of an inhibitory TTC7B selective nanobody that blocks EFR3 recruitment of PI4KA
Sushant Suresh, Alexandria L Shaw, Damilola K Akintola, Martine D. Lunke, Sophia Doerr, Pooja Rohilla, Tamás Balla, Calvin K. Yip, Scott D. Hansen, Jennifer A. Cobb, John E. Burke
The paper develops a nanobody that selectively blocks EFR3 recruitment of PI4KA by targeting TTC7B, reducing membrane recruitment and PI4P production.
Journal of Biological Chemistry · Nov 4, 2025Peer-reviewedBiochemistry