Sophia Doerr

This study identifies phosphorylation of Y2090 in PI4KA as an inhibitory mechanism that suppresses its lipid kinase activity through conformational changes and reduced membrane recruitment.

This study reconstitutes Ras-PI3Kγ membrane communication and feedback using light-induced signaling inputs, revealing how feedback and diffusion shape spatiotemporal signaling dynamics.

This study identifies two SHIP1 localization modes during neutrophil chemotaxis, regulated by FBP17 and Nck1, and shows that the C-terminal domain is essential for proper chemotaxis.

The paper develops a nanobody that selectively blocks EFR3 recruitment of PI4KA by targeting TTC7B, reducing membrane recruitment and PI4P production.

This study shows that lateral cell polarization, mediated by Lgl, is essential for epithelial organization in sea anemone embryos and aggregates.