Modeling predicts a biochemical feedback mechanism underlying astrocyte calcium refractory periods
James Cheng Peng, Katharina Merten, Mary Kaye Duff, Nicholas A. Nelson, Yizhi Wang, Daniela Duarte, Yue Wang, Lin Tian, Axel Nimmerjahn, Guoqiang Yu
The paper develops a computational model of astrocytic calcium signaling that predicts refractory periods through a feedback mechanism involving cPKC, validated with in vivo imaging data.
bioRxiv · Jan 13, 2026 · PreprintNeuroscience