Axel Nimmerjahn

Compact red-shifted near-infrared fluorescent proteins enable deep-tissue SWIR imaging with in vivo optical clearing.

The paper develops red-shifted near-infrared fluorescent proteins for deep-tissue SWIR imaging, showing improved signal and imaging depth in vivo.

Synthetic multicolor antigen-stabilizable nanobody platform for intersectional labelling and functional imaging.

The paper introduces a synthetic nanobody platform for multicolor labeling and functional imaging, enabling precise tracking of protein dynamics and cellular processes.

AQuA2-Cloud: a web platform for fluorescence bioimaging activity analysis

AQuA2-Cloud provides a web platform for analyzing fluorescence bioimaging data, enabling cloud-based activity quantification with improved accessibility and usability compared to the original AQuA2 tool.

Modeling predicts a biochemical feedback mechanism underlying astrocyte calcium refractory periods

The paper develops a computational model of astrocytic calcium signaling that predicts refractory periods through a feedback mechanism involving cPKC, validated with in vivo imaging data.

Fast, Accurate, and Versatile Data Analysis Platform for the Quantification of Molecular Spatiotemporal Signals

AQuA2 quantifies molecular spatiotemporal signals from live imaging data by decomposing complex datasets into signaling events, demonstrating applications across biosensors and cell types.

Multiplex, translaminar imaging in the spinal cord of behaving mice

This paper develops a new imaging system to study spinal cord activity in behaving mice, revealing lamina-specific calcium responses in astrocytes and pain-related activity in Tac1 neurons.

Trans-segmental imaging in the spinal cord of behaving mice

This study develops a wearable macroscope to image spinal cord activity in behaving mice and finds that painful stimuli trigger coordinated astrocyte excitation across multiple spinal segments.

Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits

This paper introduces a minimally invasive coaxial microprobe for multi-modal neural interfacing, enabling efficient electrical and optical interrogation with reduced inflammation.

Astrocytes encode complex behaviorally relevant information

The paper shows astrocytes encode behaviorally relevant information through calcium transients during a visual detection task, complementing neuronal coding.

Calcium Imaging Reveals Host-Graft Synaptic Network Formation in Spinal Cord Injury

The paper uses calcium imaging to show that neural progenitor cell grafts form functional synaptic networks in spinal cord injury sites, mirroring normal spinal cord patterns.