Aberrant TNF signaling in pancreatic lymph nodes of patients with Type 1 Diabetes
Maryam Abedi, Priyadarshini Rai, Yeqiao Zhou, Chengyang Liu, Isabelle Johnson, Aditi Chandra, Maria Fasolino, Susan Y Rostami, Klaus H. Kaestner, Ali Naji, Robert B. Faryabi, Golnaz Vahedi
This study identifies heightened TNF pathway activity and chromatin remodeling in pancreatic lymph node CD4+ T cells from T1D patients, supporting the use of TNF inhibitors in clinical trials.
bioRxiv · May 31, 2024 · PreprintImmunology