Aditi Chandra

The paper uses single-allele chromatin tracing to show that genomic clustering of paralogous transcription factors enables developmental robustness in T cells by allowing compensatory interactions when regulatory elements are lost.

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

This study identifies heightened TNF pathway activity and chromatin remodeling in pancreatic lymph node CD4+ T cells from T1D patients, supporting the use of TNF inhibitors in clinical trials.

The paper develops HiDRO, a high-throughput imaging pipeline, to screen the human druggable genome and identifies >300 factors regulating chromatin folding, including GSK3A as a regulator of TAD interactions.

Stripenn detects and quantifies architectural stripes from chromatin conformation data using computer vision, outperforming existing methods in biological applications.