This study identifies new genetic loci associated with myocardial infarction and coronary heart disease using genome-wide association analyses across multiple cohorts.

PLoS ONE · Nov 13, 2020Peer-reviewedGenetics

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction

Ιωάννα Ντάλλα, Lu-Chen C Weng, James Cartwright, Amelia Weber Hall, Garðar Sveinbjörnsson, Nathan R. Tucker, Seung Hoan Choi, Mark D. Chaffin, Carolina Roselli, Michael R. Barnes, Borbála Mifsud, Helen R. Warren, Caroline Hayward, Jonathan Marten, James J. Cranley, , Dan M. Roden

This study identifies 210 genetic loci associated with the PR interval through multi-ancestry GWAS, highlighting their role in cardiac conduction and cardiovascular disease.

bioRxiv · Jul 30, 2019 · PreprintGenetics

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

Raymond Noordam, Maxime M. Bos, Heming Wang, Thomas W. Winkler, Amy R. Bentley, Tuomas O. Kilpeläinen, Paul S. de Vries, Yun Ju Sung, Karen Schwander, Brian E. Cade, Alisa Knodle Manning, Hugues Aschard, Michael R Brown, Han Chen, Nora Franceschini, , André Gerardus Uitterlinden

The paper identifies 49 novel blood lipid loci associated with gene-sleep interactions in 126,926 individuals across 5 ancestry groups, with gene-short-sleep interactions explaining 4.25% of triglyceride variance.

bioRxiv · Feb 25, 2019 · PreprintGenomics

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

Sara L. Pulit, Lu-Chen C Weng, Patrick F. McArdle, Ludovic Trinquart, Seung Hoan Choi, Braxton D. Mitchell, Jonathan M. Rosand, Paul I. W. de Bakker, Emelia J. Benjamin, Patrick T. Ellinor, Steven J. Kittner, Steven A. Lubitz, Christopher D. Anderson, Ingrid E. Christophersen, Michiel Rienstra, , Eric Boerwinkle

The paper assesses if genetic risk for atrial fibrillation explains cardioembolic stroke risk using genome-wide data from the Stroke Genetics Network.

Neurology Genetics · Dec 1, 2018Peer-reviewedGenetics

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

Annah B. Wyss, Tamar Sofer, Mi Kyeong Lee, Natalie Terzikhan, Jennifer N. Nguyen, Lies Lahousse, Jeanne C. Latourelle, Albert V. Smith, Traci M. Bartz, Mary Furlan Feitosa, Wei Dong Gao, Tarunveer S. Ahluwalia, Wenbo Tang, Christopher J. Oldmeadow, Qing Duan, , Josée Dupuis

This study identifies over 50 new genetic loci associated with pulmonary function through a multiethnic meta-analysis of 90,715 individuals.

Nature Communications · Jul 24, 2018Peer-reviewedGenetics

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

Gail Davies, Max Lam, Sarah E. Harris, Joey W. Trampush, Michelle Luciano A, William David Hill, Saskia P. Hagenaars, Stuart James Ritchie, Riccardo Emilio Marioni, Chloe Fawns‐Ritchie, David C M Liewald, Judith A. Okely, Ari Ahola‐Olli, Catriona L. K. Barnes, Lars Bertram, , Luca Kleineidam

This study identifies 99 genetic loci associated with general cognitive function using data from 280,360 individuals, finding genes linked to brain structure and neurodegenerative disorders.

Nature Communications · May 22, 2018Peer-reviewedGenetics

Discovering patterns of pleiotropy in genome-wide association studies

Jianan Zhana, CHARGE ECG Working Group, Jessica van Setten, Jennifer A. Brody, Brenton R. Swenson, Anne M. Butler, Harry Campbell, Fabiola Del Greco M, Daniel S. Evans, Quince Gibson, Daniel Fannar Gudbjartsson, Kathleen F. Kerr, Bouwe P. Krijthe, Leo‐Pekka Lyytikäinen, Christian Müller, , Steven Ron Cummings

This paper introduces SAPPHO methods to detect pleiotropy in GWAS by modeling shared patterns of genetic associations, finding 16 additional and 124 novel loci in meta-analysis.

bioRxiv · Feb 28, 2018 · PreprintGenetics

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Jessica van Setten, Jennifer A. Brody, Yalda Jamshidi, Brenton R. Swenson, Anne M. Butler, Harry Campbell, M. Fabiola Del Greco, Daniel S. Evans, Quince Gibson, Daniel Fannar Gudbjartsson, Kathleen F. Kerr, Bouwe P. Krijthe, Leo‐Pekka Lyytikäinen, Christian Müller, Martina Müller‐Nurasyid, , Paolo Gasparini

This study identifies 47 novel genetic loci associated with PR interval through genome-wide association meta-analysis across multiple populations.

bioRxiv · Jan 17, 2018 · PreprintGenetics

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove, Traci M. Bartz, Ma’en Obeidat, Michael A. Province, Wei Dong Gao, Beenish Qaiser, David John Porteous, Patricia A. Cassano, Tarunveer S. Ahluwalia, Niels Grarup, Jin Li, , Sven Gläser

Wellcome Open Research · Jan 12, 2018Peer-reviewedGenetics

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

Claudia Liliana Satizábal, Hieab H.H. Adams, Derrek P. Hibar, Charles C. White, Jason L. Stein, Markus R. Scholz, Muralidharan Sargurupremraj, Neda Jahanshad, Albert V. Smith, Joshua C. Bis, Xueqiu Jian, Michelle Luciano A, Edith Hofer, Alexander Teumer, Sven J. van der Lee, , Lachlan T. Strike

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.

bioRxiv · Aug 28, 2017 · PreprintGenetics

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

Louise V. Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J. van der Most, Abdullah Mesut Erzurumluoglu, Paul F. O’Reilly, Claudia P. Cabrera, Helen R. Warren, Lynda M. Rose, Germaine C. Verwoert, Jouke‐Jan Hottenga, Rona J. Strawbridge, Tõnu Esko, Dan E. Arking, , Tamara B. Harris

This study identifies 6 new blood pressure loci and 48 genes involved in BP regulation using GWAS and gene expression data from blood and kidney tissues.

Hypertension · Jul 24, 2017Peer-reviewedGenomics