Intrinsic immunity against HAdV is achieved by a novel epigenetic silencing complex
Julia Mai, Maryam Karimi, Anna Katharina Kuderna, Anna Heider, Thomas Günther, Caroline C. Friedel, Adam T. Grundhoff, Thomas Stamminger, Sabrina Schreiner
This study identifies the HUSH complex as a host factor that restricts HAdV infection through epigenetic silencing, and shows HAdV proteins inhibit this complex to promote viral replication.
bioRxiv · Feb 10, 2025 · PreprintCell Biology