Highly plastic macrophage niches orchestrate acquired quiescence and reactivation in breast-cancer bone metastasis
Yasuto Takeuchi, Huazi Zhang, Takahiko Murayama, Tsunaki Hongu, Kazuhiro Ikeda, Kuniko Horie, Satoshi Inoue, Masao Yano, Masahiko Tanabe, Yuki Kurokawa, Hirofumi Terakawa, Noriyuki Inaki, Kei-ichiro Tada, Etsuo A. Susaki, Eishu Hirata, , Noriko Gotoh
The paper identifies CXCL16 macrophages in bone metastases that transiently restrain cancer growth and G-CSF niches that promote reactivation, revealing CAF-bone-marrow interactions as a therapeutic target.
bioRxiv · Sep 1, 2026 · PreprintCancer Biology