Author

Tsunaki Hongu

Kanazawa UniversityORCID 0000-0002-8772-8111Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Noriko GotohiD· 3 shared Huazi ZhangiD· 2 shared Koji OkamotoiD· 2 shared Yasuto TakeuchiiD· 2 shared Arinobu TojoiD· 1 shared Eishu HirataiD· 1 shared Etsuo A. SusakiiD· 1 shared Fumio AraiiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Noriko GotohORCID

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3 papers

Recent·Most cited

Conformational dynamics of an intrinsically disordered receptor enable signal transduction

Yuma Myokan, Huazi Zhang, Tsunaki Hongu, Keisuke Sato, Saren Sarenqiqige, Katsuya Sakai, Neval Yilmaz, Kunio Matsumoto, Takashi Sumikama, Mikihiro Shibata, Noriko Gotoh

This study uses HS-AFM to directly observe conformational changes in FGFR1 during signal transduction, showing that autophosphorylation enables dynamic interactions with FRS2.

bioRxiv · Sep 4, 2026 · PreprintBiophysics

Highly plastic macrophage niches orchestrate acquired quiescence and reactivation in breast-cancer bone metastasis

Yasuto Takeuchi, Huazi Zhang, Takahiko Murayama, Tsunaki Hongu, Kazuhiro Ikeda, Kuniko Horie, Satoshi Inoue, Masao Yano, Masahiko Tanabe, Yuki Kurokawa, Hirofumi Terakawa, Noriyuki Inaki, Kei-ichiro Tada, Etsuo A. Susaki, Eishu Hirata, , Noriko Gotoh

The paper identifies CXCL16 macrophages in bone metastases that transiently restrain cancer growth and G-CSF niches that promote reactivation, revealing CAF-bone-marrow interactions as a therapeutic target.

bioRxiv · Sep 1, 2026 · PreprintCancer Biology

Mitochondrial one-carbon enzyme MTHFD1L sustains stemness and metastatic progression in breast cancer

Hirokazu KUSUNOKI, Tsunaki Hongu, Tatsunori Nishimura, Kazuki Ogawa, Jin Lee, Yasuto Takeuchi, Koji Okamoto, Tomoyoshi Soga, Noriko Gotoh

This study identifies MTHFD1L as a critical regulator of breast cancer stemness and metastasis, showing its role in metabolic rewiring and tumor progression.

bioRxiv · Jun 19, 2026 · PreprintCancer Biology