Noriko Gotoh

This study uses HS-AFM to directly observe conformational changes in FGFR1 during signal transduction, showing that autophosphorylation enables dynamic interactions with FRS2.

The paper identifies CXCL16 macrophages in bone metastases that transiently restrain cancer growth and G-CSF niches that promote reactivation, revealing CAF-bone-marrow interactions as a therapeutic target.

This study identifies MTHFD1L as a critical regulator of breast cancer stemness and metastasis, showing its role in metabolic rewiring and tumor progression.