Differential effects of MATR3 variants on its cryptic splicing repression function
Mashiat Khan, Xiao Xiao Chen, Michelle Dias, Jhune Rizsan Santos, Sukhleen Kour, Justin You, Rebekah van Bruggen, Mohieldin Youssef, Ying‐Wooi Wan, Zhandong Liu, Jill Anne Rosenfeld, Qiumin Tan, Udai Bhan Pandey, Hari Krishna Yalamanchili, Jeehye Park
This study investigates how MATR3 variants affect cryptic splicing repression, showing that some variants reduce protein solubility and impair RNA binding and splicing regulation.
FEBS Letters · Feb 1, 2024Peer-reviewedMolecular Biology