Author

Mohieldin Youssef

Hospital for Sick ChildrenORCID 0000-0002-4657-0768Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Jeehye ParkiD· 3 shared Jhune Rizsan SantosiD· 3 shared Justin YouiD· 3 shared Hari Krishna YalamanchiliiD· 2 shared Jooyun LeeiD· 2 shared Katarina Maksimovic· 2 shared Mark N Metri· 2 shared Michelle Dias· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersNeuroscience

Jeehye ParkORCID

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Author profile →

5 papers

Recent·Most cited

Early MATR3 loss and distinct neurodegenerative molecular signatures precede the onset of neuropathology in motor neurons and Purkinje cells of MATR3 S85C knock-in mouse model of ALS

Katarina Maksimovic, Majji Rambabu, Jhune Rizsan Santos, Cadia Chan, Anneka Zelaya, Jooyun Lee, Michelle Dias, Oxana B. Gluscencova, Mohieldin Youssef, Sandra Kim, Tiara Noronha, Christine Lai, Y. B. Fan, Mark N Metri, Justin You, , Jeehye Park

bioRxiv · Aug 31, 2026 · PreprintNeuroscience

Knockout of Dectin-1 does not modify disease onset or progression in a MATR3 S85C knock-in mouse model of ALS

Justin You, Katarina Maksimovic, Mark N Metri, Anneka Schoeppe, Karin Chen, Jooyun Lee, Jhune Rizsan Santos, Mohieldin Youssef, Michael W. Salter, Jeehye Park

Heliyon · Sep 1, 2024Peer-reviewedNeuroscience

Differential effects of MATR3 variants on its cryptic splicing repression function

Mashiat Khan, Xiao Xiao Chen, Michelle Dias, Jhune Rizsan Santos, Sukhleen Kour, Justin You, Rebekah van Bruggen, Mohieldin Youssef, Ying‐Wooi Wan, Zhandong Liu, Jill Anne Rosenfeld, Qiumin Tan, Udai Bhan Pandey, Hari Krishna Yalamanchili, Jeehye Park

This study investigates how MATR3 variants affect cryptic splicing repression, showing that some variants reduce protein solubility and impair RNA binding and splicing regulation.

FEBS Letters · Feb 1, 2024Peer-reviewedMolecular Biology

TOB is an effector of the hippocampus-mediated acute stress response

Mohieldin Youssef, Hiro Taiyo Hamada, Suk‐King Lai, Yuji Kiyama, Mohamed El‐Tabbal, Hiroshi Kiyonari, Kohei Nakano, Bernd Kühn, Tadashi S. Yamamoto

This study investigates the role of TOB in hippocampal stress response, showing increased TOB levels after acute stress and altered neural circuits and behavior in Tob-KO mice.

Translational Psychiatry · Jul 29, 2022Peer-reviewedNeuroscience

Synaptotagmin 2 is ectopically overexpressed in excitatory presynapses of a widely used CaMK2a-Cre mouse line

Ken Matsuura, Haytham Mohamed Aly Mohamed, Mohieldin Youssef, Yutaka Yoshida, Tadashi S. Yamamoto

The paper identifies ectopic overexpression of synaptotagmin 2 in CamiCre mice, leading to functional phenotypes and highlighting issues with Cre driver line interpretation.

iScience · Jun 30, 2022Peer-reviewedGenetics