Author

Mateusz Mendel

F. Hoffmann-La Roche AG

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Ahmed HaideriD· 1 shared Alessandro BrigoiD· 1 shared Andreas ToppiD· 1 shared Anisha Mani· 1 shared Bernd KuhniD· 1 shared Claudia Bonardi· 1 shared James Keaney· 1 shared Jörg Benz· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Ahmed HaiderORCID

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1 paper

Recent·Most cited

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses

Anisha Mani, Mateusz Mendel, Paul Westwood, Claudia Bonardi, Wiebke Saal, Andreas Topp, Matthew Bilyard, Alessandro Brigo, Matthias Wittwer, Jörg Benz, Bernd Kuhn, Ahmed Haider, Maude Giroud, James Keaney

This study shows that low doses of SARM1 base-exchange inhibitors paradoxically increase SARM1 activity and worsen neurodegeneration in vitro and in vivo.

npj Drug Discovery. · Jun 18, 2025Peer-reviewedNeuroscience