Ahmed Haider

The paper designs and evaluates novel PET tracers for CYP46A1 by modifying cyclopropyl groups, showing high affinity and suitable radiosynthesis.

This study shows that low doses of SARM1 base-exchange inhibitors paradoxically increase SARM1 activity and worsen neurodegeneration in vitro and in vivo.

This study develops and evaluates [18F]P4B-2412 as a PET radioligand for imaging PDE4B, showing high binding, specificity, and metabolic stability in rodent models.

This study evaluates CB2R expression and pyridine-based radiotracers in a mouse model of Alzheimer's disease, finding increased CB2R in glial cells but no significant mRNA differences.

This study uses PET and MRI to assess CB2R levels and metabolic changes in a mouse model of cerebral ischemia, finding increased CB2R and reduced glucose metabolism in the ischemic striatum.

This paper develops and evaluates [11C]26, a PET probe for imaging PDE7 in the brain, showing promising in vitro performance and moderate specific binding in nonhuman primates.