Author

Andreas Topp

F. Hoffmann-La Roche AGORCID 0009-0002-5511-2870Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Paul WestwoodiD· 2 shared Ahmed HaideriD· 1 shared Alessandro BrigoiD· 1 shared Alex A. HennemaniD· 1 shared Alexandra ValeanuiD· 1 shared Alger Lazo Mori· 1 shared Anisha Mani· 1 shared Antonius P. A. JansseniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Paul WestwoodORCID

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2 papers

Recent·Most cited

Neurosciencenpj Drug Discovery.Peer-reviewedJun 18, 2025

SARM1 base-exchange inhibitors induce SARM1 activation and neurodegeneration at low doses

Anisha Mani, Mateusz Mendel, Paul Westwood…·James Keaney

This study shows that low doses of SARM1 base-exchange inhibitors paradoxically increase SARM1 activity and worsen neurodegeneration in vitro and in vivo.

13 citationstop 5%

mouseexperimental assay

𝕏 PostBluesky

Cancer BiologyMolecular & Cellular ProteomicsPeer-reviewedApr 6, 2025

CellEKT: A robust chemical proteomics workflow to profile cellular target engagement of kinase inhibitors

Joel Rüegger, Berend Gagestein, Antonius P. A. Janssen…·Mario van der Stelt

CellEKT profiles cellular target engagement of kinase inhibitors using chemical proteomics to determine IC50 values across over 300 kinases and validate results with phosphoproteomics and NanoBRET.

10 citations

humanproteomics

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