Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissue
Andrew T. Song, Renata Sindeaux, Yuanyi Li, Hicham Affia, Tapan Agnihotri, Séverine Leclerc, Patrick Piet Van Vliet, Mathieu Colas, Jean-Victor Guimond, Natasha Patey, Jean‐Sébastien Joyal, Élie Haddad, Luis Bruno Barreiro, Grégor Andelfinger
The paper develops a human intestinal organoid model with macrophages to study their role in development, finding that macrophages regulate metabolism and growth without affecting tissue architecture.
bioRxiv · Sep 9, 2022 · PreprintDevelopmental Biology