Séverine Leclerc

Transcriptional dynamics of the murine heart during perinatal development at single-cell resolution

This study uses single-cell RNA-seq to analyze transcriptional changes in mouse hearts during perinatal development, identifying gene regulatory patterns and a cell type-independent imprinted gene signature.

Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer

This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.

Enhancing adult neuroplasticity by epigenetic regulation of Parvalbumin-expressing GABAergic cells

This study shows that reducing Hdac2 in PV+ cells enhances fear memory extinction in adults by downregulating Acan, a perineuronal net component.

Developmental role of macrophages modelled in human pluripotent stem cell derived intestinal tissue

The paper develops a human intestinal organoid model with macrophages to study their role in development, finding that macrophages regulate metabolism and growth without affecting tissue architecture.