Revealing Functional Hotspots: Temperature-Dependent Crystallography of K-RAS Highlights Allosteric and Druggable Sites
Samuel L. Deck, Megan Xu, Matt Stankus, Shawn K. Milano, Richard A. Cerione
This study uses multi-temperature X-ray crystallography to reveal temperature-dependent conformational changes in K-RAS, identifying new druggable sites and highlighting the limitations of cryogenic conditions in capturing dynamic states.
bioRxiv · Feb 27, 2025 · PreprintBiochemistry