Author

Megan Xu

Cornell UniversityORCID 0000-0003-1231-2784Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Matt Stankus· 1 shared Richard A. CerioneiD· 1 shared Samuel L. DeckiD· 1 shared Shawn K. MilanoiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBiochemistry

Matt Stankus

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintFeb 27, 2025

Revealing Functional Hotspots: Temperature-Dependent Crystallography of K-RAS Highlights Allosteric and Druggable Sites

Samuel L. Deck, Megan Xu, Matt Stankus…·Richard A. Cerione

This study uses multi-temperature X-ray crystallography to reveal temperature-dependent conformational changes in K-RAS, identifying new druggable sites and highlighting the limitations of cryogenic conditions in capturing dynamic states.

DOI 10.1101/2025.02.27.639303

humanprotein structure

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