Trapped Topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeast
Nicole Stantial, Anna T. Rogojina, Matthew A. Gilbertson, Yilun Sun, Hannah N. Miles, Samantha Shaltz, James M. Berger, Karin C. Nitiss, Sue Jinks-Robertson, John L. Nitiss
This study identifies a yeast Top2 mutant that generates stabilized cleavage intermediates, leading to de novo duplications via nonhomologous end-joining.
Proceedings of the National Academy of Sciences · Oct 12, 2020Peer-reviewedMolecular Biology