Yilun Sun

This study shows that Q901, a CDK7 inhibitor, enhances cancer susceptibility to TOP1 inhibitors by stabilizing TOP1-DPCs and suppressing DNA repair pathways.

This study shows that HDAC inhibition with entinostat enhances immunotherapy response in SCLC by reprogramming tumor immunology and neuroendocrine status.

This study identifies TOP3A's role in ALT telomere maintenance, showing its enrichment at ALT telomeres and its impact on TERRA and TERF2 stability.

This paper identifies SEMA7A as a prognostic biomarker in adrenocortical carcinoma using transcriptome data from TCGA and NCI samples, showing its association with poor prognosis and specific signaling pathways.

This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.

This study identifies FA-induced DNA-protein crosslinks (DPCs) and discovers that FEN1 repairs them via PARylation, revealing a novel PARP1-FEN1 pathway for DPC repair.

The paper maps genome-wide topoisomerase binding sites to identify TOP3A as a sensor of transcription-replication conflicts.

The paper identifies p97 ATPase as a key player in removing trapped PARP1 from chromatin, enhancing PARPi-induced cytotoxicity in homologous recombination-defective cells.

The paper identifies a conserved SUMO-Ubiquitin pathway involving PIAS4 and RNF4 that mediates proteasomal degradation of topoisomerase DNA-protein crosslinks in human and yeast cells.

This study identifies a yeast Top2 mutant that generates stabilized cleavage intermediates, leading to de novo duplications via nonhomologous end-joining.