A conserved SUMO-Ubiquitin pathway directed by RNF4/SLX5-SLX8 and PIAS4/SIZ1 drives proteasomal degradation of topoisomerase DNA-protein crosslinks
Yilun Sun, Lisa M. Miller Jenkins, Yijun P. Su, Karin C. Nitiss, John L. Nitiss, Yves G. Pommier
The paper identifies a conserved SUMO-Ubiquitin pathway involving PIAS4 and RNF4 that mediates proteasomal degradation of topoisomerase DNA-protein crosslinks in human and yeast cells.
Science Advances · Nov 13, 2020Peer-reviewedMolecular Biology