A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer.
Marine Berquez, Alexander L. Li, Matthew A. Luy, Anthony C. Venida, Simon McDowall, Thomas O'loughlin, Gilles Rademaker, Abhilash Barpanda, Jingjie Hu, Julian Yano, Arun P. Wiita, Luke A. Gilbert, Peter M. Bruno, Rushika M. Perera
This study identifies a multi-subunit autophagic capture complex that degrades ER-stalled MHC-I in pancreatic cancer, reducing immunogenicity.
Molecular Cell · May 29, 2026Peer-reviewedCancer Biology