Force sensing by Piezo1 regulates endothelial secretory granule exocytosis
Sammy El-Mansi, Mina Al-Saegh, Loïc Rolas, Matthew Golding, Mathieu-Benoı̂t Voisin, Sussan Nourshargh, Thomas D. Nightingale
This paper shows that Piezo1 mechanosensing triggers endothelial Weibel-Palade body exocytosis, linking mechanical forces to inflammation and haemostasis through VWF release and leukocyte capture.
bioRxiv · Sep 26, 2025 · PreprintCell Biology