Sammy El-Mansi

This paper shows that Piezo1 mechanosensing triggers endothelial Weibel-Palade body exocytosis, linking mechanical forces to inflammation and haemostasis through VWF release and leukocyte capture.

This study identifies β-PIX as a regulator of VWF secretion from endothelial cells by enabling cytoskeletal reorganisation during WPB exocytosis.