Dynamic Responses of Striatal Cholinergic Interneurons Control the Extinction and Updating of Goal-Directed Learning
Zhenbo Huang, Ruifeng Chen, Matthew Ho, Xueyi Xie, Xuehua Wang, Jun Wang
This study shows that burst firing of striatal cholinergic interneurons promotes extinction learning, while their pause is critical for reversing goal-directed behavior, and alcohol disrupts this process.
bioRxiv · Nov 9, 2023 · PreprintNeuroscience