Ruifeng Chen

This study examines how chronic alcohol exposure affects corticostriatal circuits and pathology in two Alzheimer's disease mouse models, revealing distinct effects on Aβ and tau-driven pathologies.

This study shows that burst firing of striatal cholinergic interneurons promotes extinction learning, while their pause is critical for reversing goal-directed behavior, and alcohol disrupts this process.

This paper shows that drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic interneurons through enhanced inhibitory transmission from direct-pathway medium spiny neurons.