Potentiating NaV1.1 in Dravet syndrome patient iPSC-derived GABAergic neurons increases neuronal firing frequency and decreases network synchrony
Matt R. Kelley, Laura B. Chipman, Shoh M. Asano, Matthew Knott, Samantha Howard, Allison P. Berg
This study shows that enhancing NaV1.1 in Dravet syndrome patient neurons increases firing rates and reduces network synchrony using HD-MEAs.
bioRxiv · Sep 28, 2023 · PreprintNeuroscience