Modifying Azithromycin to Mitigate Arrested Autophagy
Ryan D. Quarrington, Shiye Chen, Sylvia A. Sapula, Shawn W H Liu, Susan Elizabeth Lester, Matthew M Miller, Vesna Munić Kos, Benjamin T. Kopp, Hubertus P. A. Jersmann, Anton Blencowe, Eugene Roscioli
This paper shows azithromycin inhibits autophagy and presents a modified version, AZM-[O], that reduces this effect while retaining antimicrobial and immunomodulatory functions.
bioRxiv · Apr 25, 2024 · PreprintBiochemistry