MAPK Signaling and Angiopoietin-2 Contribute to Endothelial Permeability in Capillary Malformations
Sana Nasim, Mariam Baig, Jill Wylie‐Sears, Matthew P. Vivero, Patrick J. Smits, Annegret Holm, Leanna Marrs, Yu Sheng Cheng, Cesar Alves, Anna Pinto, Arin K. Greene, Joyce E. Bischoff
This study identifies GNAQ R183Q mutation-induced endothelial barrier dysfunction in capillary malformations and shows that targeting MAPK signaling and ANGPT2 can restore barrier integrity.
Proceedings of the National Academy of Sciences · Nov 19, 2025Peer-reviewedPathology