Author

Leanna Marrs

Boston Children's HospitalORCID 0009-0001-8791-5136Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Arin K. GreeneiD· 2 shared Joyce E. BischoffiD· 2 shared Patrick J. SmitsiD· 2 shared Sana NasimiD· 2 shared Yu Sheng ChengiD· 2 shared Anna PintoiD· 1 shared Annegret HolmiD· 1 shared Cesar AlvesiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPathology

Arin K. GreeneORCID

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2 papers

Recent·Most cited

PathologyProceedings of the National Academy of SciencesPeer-reviewedNov 19, 2025

MAPK Signaling and Angiopoietin-2 Contribute to Endothelial Permeability in Capillary Malformations

Sana Nasim, Mariam Baig, Jill Wylie‐Sears…·Joyce E. Bischoff

This study identifies GNAQ R183Q mutation-induced endothelial barrier dysfunction in capillary malformations and shows that targeting MAPK signaling and ANGPT2 can restore barrier integrity.

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humanbulk RNA-seq

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Cell BiologyAngiogenesisPeer-reviewedJun 11, 2025

An endothelial specific mouse model for the capillary malformation mutation Gnaq p.R183Q

Patrick J. Smits, Leanna Marrs, Yu Sheng Cheng…·Arin K. Greene

This paper develops a mouse model expressing GNAQ p.R183Q in endothelial cells to study capillary malformation, showing it causes vascular malformations similar to human CM.

7 citationstop 3%

mouseexperimental assay

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