Author

Patrick J. Smits

Boston Children's HospitalORCID 0000-0002-4552-6730Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Arin K. GreeneiD· 2 shared Joyce E. BischoffiD· 2 shared Leanna MarrsiD· 2 shared Sana NasimiD· 2 shared Yu Sheng ChengiD· 2 shared Anna PintoiD· 1 shared Annegret HolmiD· 1 shared Cesar AlvesiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPathology

Arin K. GreeneORCID

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2 papers

Recent·Most cited

MAPK Signaling and Angiopoietin-2 Contribute to Endothelial Permeability in Capillary Malformations

Sana Nasim, Mariam Baig, Jill Wylie‐Sears, Matthew P. Vivero, Patrick J. Smits, Annegret Holm, Leanna Marrs, Yu Sheng Cheng, Cesar Alves, Anna Pinto, Arin K. Greene, Joyce E. Bischoff

This study identifies GNAQ R183Q mutation-induced endothelial barrier dysfunction in capillary malformations and shows that targeting MAPK signaling and ANGPT2 can restore barrier integrity.

Proceedings of the National Academy of Sciences · Nov 19, 2025Peer-reviewedPathology

An endothelial specific mouse model for the capillary malformation mutation Gnaq p.R183Q

Patrick J. Smits, Leanna Marrs, Yu Sheng Cheng, Michal Ad, Sana Nasim, David Zurakowski, Joyce E. Bischoff, Arin K. Greene

This paper develops a mouse model expressing GNAQ p.R183Q in endothelial cells to study capillary malformation, showing it causes vascular malformations similar to human CM.

Angiogenesis · Jun 11, 2025Peer-reviewedCell Biology