Jill Wylie‐Sears

This study identifies GNAQ R183Q mutation-induced endothelial barrier dysfunction in capillary malformations and shows that targeting MAPK signaling and ANGPT2 can restore barrier integrity.

The paper identifies a SOX18-mevalonate pathway axis in infantile hemangioma and suggests repurposing statins as a treatment.

This study shows that deleting CD45 in endothelial cells reduces atherosclerosis by inhibiting EndoMT and TGFβ signaling through increased FGFR2 and KLF2 expression.

This study shows R(+) propranolol reduces lipid accumulation in hemangioma-derived stem cells in vitro and in a mouse model, without affecting adipogenic transcription factors.

This paper shows that PROX1 inhibits PDGF-B expression in heart valves to prevent myxomatous degeneration, and PDGF-B inhibition ameliorates valve defects in mice.