Focused Ultrasound Blood-Tumor Barrier Opening Rapidly Augments Intratumor CD4 and CD8 T Cell Representation in a Genetically Engineered Mouse Model of Glioma
Katherine M. Nowak, Matthew R. Hoch, William B. Gillespie, Claire A Conarroe, Victoria R. Breza, Tanya Cruz, Eden N. Gordon, Catherine M. Gorick, Tajie H. Harris, Joshua D. Wythe, Richard J. Price
This study shows that focused ultrasound with microbubbles opens the blood-tumor barrier in a glioma model, increasing CD4 and CD8 T cell infiltration without altering the CD8/Treg ratio.
bioRxiv · Jul 28, 2026 · PreprintCancer Biology