Author

Feijie Zhang

Stanford Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Assay:DNA methylation· 2 Research Focus:variant calling· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Katja PekruniD· 4 shared Mark A. KayiD· 4 shared Ren Song· 2 shared Adriana Gonzalez‐Sandoval· 1 shared Aranyak GoswamiiD· 1 shared Feorillo GalivoiD· 1 shared Francesco PuzzoiD· 1 shared Gustavo de Alencastro· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMolecular Biology

Katja PekrunORCID

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Author profile →

4 papers

Recent·Most cited

AAV-mediated genome editing is influenced by the formation of R-loops

Francesco Puzzo, Magdalena P. Crossley, Aranyak Goswami, Feijie Zhang, Katja Pekrun, Jada L. Garzon, Karlene A. Cimprich, Mark A. Kay

This study shows that R-loop formation enhances AAV-mediated genome integration, particularly in highly transcribed genes, and correlates with off-target integration sites.

Molecular Therapy · Oct 4, 2024Peer-reviewedMolecular Biology

Capsid-mediated chromatin state of the AAV vector genome controls host species range

Adriana Gonzalez‐Sandoval, Shinnosuke Tsuji, Feijie Zhang, King L. Hung, Howard Y. Chang, Katja Pekrun, Mark A. Kay

The paper shows that AAV capsid design affects the chromatin state of the vector genome, influencing transduction efficiency across species.

bioRxiv · Oct 6, 2022 · PreprintMolecular Biology

Selection of rAAV Vectors that Cross the Human Blood-Brain Barrier 1 and Target the Central Nervous System Using a Transwell Model

Ren Song, Katja Pekrun, Themasap A. Khan, Feijie Zhang, Sergiu P. Pașca, Mark A. Kay

The paper identifies AAV capsids with improved blood-brain barrier penetration and CNS cell selectivity using a transwell model.

Molecular Therapy — Methods & Clinical Development · Sep 7, 2022Peer-reviewedMolecular Biology

Using a bar-coded AAV capsid library to select for novel clinically relevant gene therapy vectors

Katja Pekrun, Gustavo de Alencastro, Qing-Jun Luo, Jun Liu, Young‐Jin Kim, Sean C. Nygaard, Feorillo Galivo, Feijie Zhang, Ren Song, Matthew R. Tiffany, Jianpeng Xu, Matthias Hebrok, Markus Grompe, Mark A. Kay

The paper develops a barcoded AAV capsid library to identify novel gene therapy vectors with improved transduction efficiency in human islets and hepatocytes.

JCI Insight · Nov 13, 2019Peer-reviewedGenetics