Mark A. Kay

This study shows that R-loop formation enhances AAV-mediated genome integration, particularly in highly transcribed genes, and correlates with off-target integration sites.

The paper proposes a standardized ontology for naming tRNA-derived RNAs based on molecular origin to improve inter-study comparisons.

The paper shows that AAV capsid design affects the chromatin state of the vector genome, influencing transduction efficiency across species.

The paper identifies AAV capsids with improved blood-brain barrier penetration and CNS cell selectivity using a transwell model.

The paper shows that 3'-tsRNAs are aminoacylated, originating from charged mature tRNA, and demonstrates their role in translation and cancer.

This study shows that tyrosine kinase inhibitors cause mitochondrial dysfunction in cardiomyocytes by altering GATA4-mediated networks, and GATA4 overexpression can rescue these effects.

The paper develops a barcoded AAV capsid library to identify novel gene therapy vectors with improved transduction efficiency in human islets and hepatocytes.

This paper demonstrates that allele-specific RNAi therapy reduces disease-causing mutations in a mouse model of restrictive cardiomyopathy, improving cardiac function and reducing pathological markers.