Katja Pekrun

This study shows that R-loop formation enhances AAV-mediated genome integration, particularly in highly transcribed genes, and correlates with off-target integration sites.

The paper shows that AAV capsid design affects the chromatin state of the vector genome, influencing transduction efficiency across species.

The paper identifies AAV capsids with improved blood-brain barrier penetration and CNS cell selectivity using a transwell model.

The paper develops a barcoded AAV capsid library to identify novel gene therapy vectors with improved transduction efficiency in human islets and hepatocytes.

The paper shows that the B-compartment self-organizes early in the cell cycle before associating with the nuclear lamina.

This study uses chromosome conformation paints to show that LADs form compact regions at the nuclear lamina and are linked to B compartments, with some regions interacting with the A compartment.