The structure of an Amyloid Precursor Protein/talin complex indicates a mechanical basis of Alzheimer's Disease.
Charles Ellis, Natasha L. Ward, Matthew Rice, Neil J. Ball, Pauline Walle, Chloé Najdek, Devrim Kilinc, Jean‐Charles Lambert, Julien Chapuis, Benjamin Thomas Goult
This paper presents the crystal structure of an APP/talin complex, proposing APP processing as a mechanical signalling pathway involved in synaptic homeostasis and suggesting a new hypothesis for Alzheimer's disease.
Open Biology · Nov 1, 2024Peer-reviewedNeuroscience