Author

Chloé Najdek

Inserm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:rat· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Organism:Drosophila· 1

Frequent Co-Authors

Jean‐Charles LambertiD· 4 shared Devrim KilinciD· 3 shared Julien ChapuisiD· 3 shared Pauline WalleiD· 3 shared Philippe AmouyeliD· 3 shared Audrey CouloniD· 2 shared Benjamin Grenier‐BoleyiD· 2 shared Carla GelleiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Jean‐Charles LambertORCID

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4 papers

Recent·Most cited

The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures

Nina lannette-Weimann, Marlène Huyvaert, Floriane Limoge, Morgane Lemaire, Vance Difan Gao, Florence Maurier, Karine Guyot, Charlotte Henocq, Audrey Coulon, Valérie Buiche, Florian Rabiller, Nad’a Majerníková, Pauline Walle, Sophie Desnoulez-Salomé, Bruno Neiva-Queirós, , Julie Dumont

This study identifies the rs28834970 variant in PTK2B as a risk factor for Alzheimer's disease, showing it impairs PYK2 function, increases Tau phosphorylation, and alters APP processing in human neuronal cultures.

bioRxiv · Oct 30, 2026 · PreprintGenetics

BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicity

Erwan Lambert, Carla Gelle, Valentin Leclerc, Alejandra Freire‐Regatillo, Nicolas Barois, Tommy Malfoi, Xavier Hermant, Florie Demiautte, Frank Lafont, Philippe Amouyel, K. Blary, Sabine Kuenen, Chloé Najdek, Patrik Verstreken, Dolores Siedlecki‐Wullich, , Pierre Dourlen

This study shows that BIN1 isoform 1 expression in the presynaptic compartment causes synaptotoxicity, leading to synaptic loss and structural changes in Drosophila and rat models.

bioRxiv · Aug 11, 2025 · PreprintNeuroscience

The structure of an Amyloid Precursor Protein/talin complex indicates a mechanical basis of Alzheimer's Disease.

Charles Ellis, Natasha L. Ward, Matthew Rice, Neil J. Ball, Pauline Walle, Chloé Najdek, Devrim Kilinc, Jean‐Charles Lambert, Julien Chapuis, Benjamin Thomas Goult

This paper presents the crystal structure of an APP/talin complex, proposing APP processing as a mechanical signalling pathway involved in synaptic homeostasis and suggesting a new hypothesis for Alzheimer's disease.

Open Biology · Nov 1, 2024Peer-reviewedNeuroscience

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks

Audrey Coulon, Florian Rabiller, Mari Takalo, Avishek Roy, Alexandre Pelletier, Henna Martiskainen, Dolores Siedlecki‐Wullich, Nina Lannette-Weimann, Naďa Majerníková, Arthur Grenon, Vance Difan Gao, Anaël Erhardt, Anne Pernodet, Morgane Lemaire, Floriane Limoge, , Jean‐Charles Lambert

This study shows that PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease-related markers in neurons.

bioRxiv · Apr 29, 2024 · PreprintNeuroscience