Neil J. Ball

This study identifies an internal PDZ-binding motif in Densin-180 that promotes SHANK scaffold remodelling through activity-dependent interactions.

The paper shows that the A50I vinculin mutation is not talin-binding-null and that talin is essential for organizing vinculin tension gradients in focal adhesions.

This paper identifies an aggregation-prone region in talin that drives self-interactions and regulates integrin adhesion complex dynamics through mechanical unfolding and oligomerization.

The paper identifies CCT8 as a MYO10 interactor critical for filopodia functions through proteomics and functional studies in cancer cells.

This paper identifies how CDKL5 is anchored at the postsynaptic density via interactions with PDZ domains and talin, and shows that its spatial positioning is regulated by talin's mechanical properties.

This paper presents the crystal structure of an APP/talin complex, proposing APP processing as a mechanical signalling pathway involved in synaptic homeostasis and suggesting a new hypothesis for Alzheimer's disease.