Author

Pauline Walle

InsermORCID 0009-0001-3603-9949Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:protein structure· 1 Organism:rat· 1

Frequent Co-Authors

Chloé Najdek· 3 shared Jean‐Charles LambertiD· 3 shared Julien ChapuisiD· 3 shared Audrey CouloniD· 2 shared Benjamin Grenier‐BoleyiD· 2 shared Devrim KilinciD· 2 shared Florian RabilleriD· 2 shared Floriane Limoge· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Chloé Najdek

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintOct 30, 2026

The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures

Nina lannette-Weimann, Marlène Huyvaert, Floriane Limoge…·Julie Dumont

This study identifies the rs28834970 variant in PTK2B as a risk factor for Alzheimer's disease, showing it impairs PYK2 function, increases Tau phosphorylation, and alters APP processing in human neuronal cultures.

DOI 10.64898/2026.10.26.761842

humanbulk RNA-seq

𝕏 PostBluesky

NeuroscienceOpen BiologyPeer-reviewedNov 1, 2024

The structure of an Amyloid Precursor Protein/talin complex indicates a mechanical basis of Alzheimer's Disease.

Charles Ellis, Natasha L. Ward, Matthew Rice…·Benjamin Thomas Goult

This paper presents the crystal structure of an APP/talin complex, proposing APP processing as a mechanical signalling pathway involved in synaptic homeostasis and suggesting a new hypothesis for Alzheimer's disease.

9 citations

humanprotein structure

𝕏 PostBluesky

NeurosciencebioRxivPreprintApr 29, 2024

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks

Audrey Coulon, Florian Rabiller, Mari Takalo…·Jean‐Charles Lambert

This study shows that PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease-related markers in neurons.

3 citations

rathuman

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